Protein molecular machines supporting life are far superior to synthetic molecular machines in many aspects [1, 2]. We unveil operation principles of protein molecular machines with single-molecule imaging and X-ray crystallography. With the help of saturation mutagenesis, automated screening and computational design, we also engineer non-natural protein molecular machines to understand their design principles.
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 The Nobel Prize in Chemistry 2016 "The design and synthesis of molecular machines"
 Peplow M. Nature 2015 "The tiniest Lego: a tale of nanoscale motors, rotors, switches and pumps"