秋山グループ 論文・発表一覧
- Furuike Y, Yamashita E, Akiyama S
Structure-function relationship of KaiC around dawn
Biophysics and Physicobiology; doi: 10.2142/biophysico.bppb-v21.0001 (2023)
- Mukaiyama A, Furuike Y, Yamashita E, Akiyama S
Highly sensitive tryptophan fluorescence probe for detecting rhythmic conformational changes of KaiC in the cyanobacterial circadian clock system
Biochemical Journal 479, 14, 1505-1515; doi: 10.1042/BCJ20210544 (2022).
- Furuike Y, Mukaiyama A, Koda S, Simon D, Ouyang D, Ito-Miwa K, Saito S, Yamashita E, Nishiwaki-Ohkawa T, Terauchi K, Kondo T, Akiyama S
Regulation Mechanisms of the Dual ATPase in KaiC
Proceedings of the National Academy of Sciences of the United States of America 119, e2119627119; doi: 10.1073/pnas.2119627119 (2022)
- Furuike Y, Mukaiyama A, Ouyang D, Ito-Miwa K, Simon D, Yamashita E, Kondo T, Akiyama S
Elucidation of Master Allostery Essential for Circadian Clock Oscillation in Cyanobacteria
Science Advances 8, eabm8990; doi: 10.1126/sciadv.abm8990 (2022)
- Furuike Y, Ouyang D, Tominaga T, Matsuo T, Mukaiyama A, Kawakita Y, Fujiwara S, Akiyama S
Cross-scale Analysis of Temperature Compensation in the Cyanobacterial Circadian Clock System
Communications Physics 5, 75; doi: 10.1038/s42005-022-00852-z (2022)
【プレスリリース】どうして生物の２４時間リズムは安定なのか？ー水素原子の運動から迫る時計タンパク質の温度補償制御ー
生物の24時間リズム一定に保たれる理由 分子研、QSTなど解明
科学新聞, １０面, 2022年5月20日, 掲載 - Simon D, Mukaiyama A, Furuike Y, Akiyama S
Slow and Temperature-compensated Autonomous Disassembly of KaiB-KaiC Complex
Biophysics and Physicobiology 19, e190008; doi: 10.2142/biophysico.bppb-v19.0008 (2022)
- Maruyama M, Furukawa Y, Kinoshita M, Mukaiyama A, Akiyama S, Yoshimura T
Adenylate kinase 1 overexpression increases locomotor activity in medaka fish
PLoS ONE 17, e0257967; doi: 10.1371/journal.pone.0257967 (2022)
- Akiyama S, Kamikubo H
Beyond multi-disciplinary and cross-scale analyses of the cyanobacterial circadian clock system
Biophysics and Physicobiology, doi.org/10.2142/biophysico.bppb-v18.031 (2021)
- Akiyama S
Reasons for Seeking Information on the Molecular Structure and Dynamics of Circadian Clock Components in Cyanobacteria
Circadian Rhythms in Bacteria and Microbiomes, 138-145 (2021)
- Okumura M, Kanemura S, Matsusaki M, Lee YH, Akiyama S, Inaba K
A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization
Structure 29, 1-14; doi.org/10.1016/j.str.2021.03.016 (2021)
- Ito-Miwa K, Furuike Y, Akiyama S, Kondo T
Tuning the circadian period of cyanobacteria up to 6.6 days by the single amino acid substitutions in KaiC
Proceedings of the National Academy of Sciences of the United States of America; doi.org/10.1073/pnas.2005496117 (2020)
- Anzai I, Tokuda E, Handa S, Misawa H, Akiyama S, Furukawa Y
Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation
Free Radical Biology and Medicine 147, 187-199; doi.org/10.1016/j.freeradbiomed.2019.12.017 (2020)
- Mukaiyama A, Furuike Y, Akiyama S
A kinetic mechanism gating the assembly of KaiB-KaiC complex in the cyanobacterial circadian clock system
Biological Rhythms, 29-34 (2019)
- Ouyang D, Furuike Y, Mukaiyama A, Ito-Miwa K, Kondo T, Akiyama S
Development and Optimization of Expression, Purification, and ATPase Assay of KaiC for Medium-Throughput Screening of Circadian Clock Mutants in Cyanobacteria
International Journal of Molecular Science 20, 2789-2800; doi: 10.3390/ijms20112789 (2019)
- Okumura M, Noi K, Kanemura S, Kinoshita M, Saio T, Inoue Y, Hikima T, Akiyama S, Ogura T, Inaba K
Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding
Nature Chemical Biology 15, 499-509; doi: 10.1038/s41589-019-0268-8 (2019)
- Mukaiyama A, Ouyang D, Furuike Y, Akiyama S
KaiC from a cyanobacterium Gloeocapsa sp. PCC 7428 retains functional and structural properties required as the core of circadian clock system
International Journal of Biological Macromolecules 131, 67-73; doi: 10.1016/j.ijbiomac.2019.03.051 (2019)
- 秋山 修志，古池 美彦，向山 厚
変化し続ける概日時計のかたち
時間生物学 24, 92-99 (2018)
- Furukawa Y, Lim C, Tosha T, Yoshida K, Hagai T, Akiyama S, Watanabe S, Nakagome K, Shiro Y
Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metal-associated domain
PLoS One 13, e0204355; doi: 10.1371/journal.pone.0204355 (2018)
- 秋山 修志
芸は身を助く？
生物物理 58, 181 (2018)
- Mukaiyama A, Furuike Y, Abe J, Yamashita E, Kondo T, Akiyama S
Conformational rearrangements of the C1 ring in KaiC measure the timing of assembly with KaiB
Scientific Reports 8, 8803 (2018)
- Akiyama S, Mukaiyama A, Abe J, Furuike Y
Cyanobacterial circadian clock system: how and why can it be so slow and stable?
Biological Clocks: with reference to suprachiasmatic nucleus, 73-77 (2017)
- Nuemket N, Yasui N, Kusakabe Y, Nomura Y, Atsumi N, Akiyama S, Nango E, Kato Y, Kaneko M K, Takagi J, Hosotani M, Yamashita A
Structural basis for perception of diverse chemical substances by T1r taste receptors
Nature Communications 8, 15530 (2017)
- Anzai I, Tokuda E, Mukaiyama A, Akiyama S, Endo F, Yamanaka K, Misawa H, Furukawa Y
A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis
Protein Science 26, 484-496 (2017)
- Kanemura S, Okumura M, Yutani K, Ramming T, Hikima T, Appenzeller-Herzog C, Akiyama S, Inaba K
Human ER Oxidoreductin-1α (Ero1α) Undergoes Dual Regulation through Complementary Redox Interactions with Protein-Disulfide Isomerase(PDI)
Journal of Biological Chemistry 291, 23952-23964 (2016)
- Furuike Y, Abe J, Mukaiyama A, Akiyama S
Accelerating in vitro studies on circadian clock systems using an automated sampling device
Biophysics and Physicobiology 13, 235-241; doi: 10.2142/biophysico.13.0_235 (2016)
- 秋山 修志
概日時計因子の構造や動態を調べる意義とは？
生物物理 56, 266-270 (2016)
- Anzai I, Toichi K, Tokuda E, Mukaiyama A, Akiyama S, Furukawa Y
Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral Sclerosis
Frontiers in Molecular Biosciences 3, 40; doi: 10.3389/fmolb.2016.00040 (2016)
- Nango E, Akiyama S, Maki-Yonekura S, Ashikawa Y, Kusakabe Y, Krayukhina E, Maruno T, Uchiyama S, Nuemket N, Yonekura K, Shimizu M, Atsumi N, Yasui N, Hikima T, Yamamoto M, Kobayash Y, Yamashita A
Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains
Scientific Reports 6, 25745; doi: 10.1038/srep25745 (2016)
- Abe J, Mukaiyama A, Akiyama S
Absolute slowness encoded in the circadian clock protein KaiC
SPring-8 Reserch Frontiers 2015, 24-25 (2016)
- Furukawa Y, Anzai I, Akiyama S, Imai M, Cruz FJC, Saio T, Nagasawa K, Nomura T, and Ishimori K
Conformational Disorder of the Most Immature Cu, Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis
Journal of Biological Chemistry 291, 4144-4155 (2016)
- 秋山 修志
時間生物学と放射光科学の接点
放射光 29, 56-63 (2016)
- Furukawa Y, Suzuki Y, Fukuoka M, Nagasawa K, Nakagome K, Shimizu H, Mukaiyama A, Akiyama S
A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43
Scientific Reports 6, 20576; doi: 10.1038/srep20576 (2016)
- 阿部 淳，向山 厚，秋山 修志
時計タンパク質KaiCの「遅さ」が刻み込まれた原子構造
SPring-8/SACLA利用者情報 21, 2-4 (2016)
- 向山厚 , 阿部淳 , 孫世永 , 秋山修志
タンパク質の化学反応が細胞内の時を計る
実験医学 33, 3119-3122 (2015)
- Abe J, Hiyama T B, Mukaiyama A, Son S, Mori T, Saito S, Osako M, Wolanin J,
Yamashita E, Kondo T, and Akiyama S
Atomic-scale Origins of Slowness in the Cyanobacterial Circadian Clock
Science 349, 312-316 (2015)
- Mukaiyama A, Osako M, Hikima T, Kondo T, and Akiyama S
A protocol for preparing nucleotide-free KaiC monomer
BIOPHYSICS 11, 79-84 (2015)
- Kojima R, Okumura M, Masui S, Kanemura S, Inoue M, Saiki M, Yamaguchi H, Hikima T, Suzuki M, Akiyama S and Inaba K.
Radically Different Thioredoxin Domain Arrangement of ERp46, an Efficient Disulfide Bond Introducer of the Mammalian PDI Family
Structure 22, 431-443 (2014)
- Furuike Y, Yamashita E, Akiyama S